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Current technology for the detection of most viral and bacterial pathogens, (Gram staining, fluorescent antibody tagging, etc.) while accurate, often requires a high level of expertise and a large amount of time. Unfortunately, with many viral and bacterial infections, time is often the critical factor in differentiating between an infection that is either treatable or lethal. Our lab has recently developed a detection methodology, based on reflective interferometry, which is fast and reagentless. The focus of my research is the development of small molecule libraries capable of selective recognition of both viral genomic DNA and proteinaceous bacterial toxins. In doing so, I hope to not only increase the ability to detect and successfully treat bacterial/viral infections, but also advance the overall understanding of the events that lead to a strong interaction between a small molecule and its target(s).
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