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Research SummaryResearch in the Miller group focuses on the fundamental goal of understanding the structure, function, and molecular interactions of biomolecules through the design, synthesis, and structural analysis of novel small-molecule ligands. In particular, our efforts center on the binding (and mimicry) of cell-surface carbohydrates and protein subdomains. Addressing this goal requires advances in our understanding of the factors underlying molecular recognition, our ability to synthesize complex molecules, and in analytical methods. In collaboration with the research groups of Phillipe Fauchet, Lewis Rothberg, and Todd Krauss in the Center for Future Health at the University of Rochester, our group is working towards the development of novel organic receptors that are specific for a variety of human pathogens (with particular focus on the skin), and integration of such receptors into optical devices. We have recently successfully used this technology to demonstrate the first highly selective sensor for Gram-(-) bacteria, and a new chip-based molecular beacon technique. Such novel sensors capable of detecting and identifying human pathogens have the promise of providing a significant positive impact on human health. |
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